DIS3
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [ISO]
- exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [ISO]
- mitotic sister chromatid segregation [IMP]
- ncRNA catabolic process [ISO]
- nonfunctional rRNA decay [ISO]
- nuclear polyadenylation-dependent mRNA catabolic process [ISO]
- nuclear polyadenylation-dependent rRNA catabolic process [ISO]
- nuclear polyadenylation-dependent tRNA catabolic process [ISO]
- nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [ISO]
- nuclear-transcribed mRNA catabolic process, non-stop decay [ISO]
- positive regulation of Ran GTPase activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DCR1
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA processing [IDA]
- cellular protein localization [IMP]
- chromatin silencing by small RNA [TAS]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- establishment of chromatin silencing at silent mating-type cassette [IMP]
- production of siRNA involved in RNA interference [IDA]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function.
BACKGROUND: Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in chromosome segregation during mitosis is only poorly understood. The Dis3 ribonuclease is a key component of the RNA-processing exosome complex. Previous isolation of the dis3-54 cold-sensitive mutant of fission yeast Schizosaccharomyces pombe suggested that Dis3 is also required for correct ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DCR1 DIS3 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 435290 |
Curated By
- BioGRID