BAIT
NCOR1
N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR
nuclear receptor corepressor 1
GO Process (14)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of JNK cascade [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, TAS]
- regulation of fatty acid transport [IC]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NR1D1
EAR1, THRA1, THRAL, ear-1, hRev
nuclear receptor subfamily 1, group D, member 1
GO Process (23)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IMP]
- circadian regulation of gene expression [ISS]
- circadian temperature homeostasis [ISS]
- gene expression [TAS]
- glycogen biosynthetic process [ISS]
- intracellular receptor signaling pathway [TAS]
- negative regulation of receptor biosynthetic process [IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of bile acid biosynthetic process [ISS]
- positive regulation of cholesterol homeostasis [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- proteasomal protein catabolic process [ISS]
- regulation of cholesterol homeostasis [ISS]
- regulation of circadian rhythm [ISS]
- regulation of fat cell differentiation [ISS]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- regulation of lipid metabolic process [ISS]
- regulation of type B pancreatic cell proliferation [ISS]
- response to leptin [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA]
- heme binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription corepressor binding [IDA, IMP]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA]
- heme binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription corepressor binding [IDA, IMP]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors.
Rev-erbA alpha and RVR/Rev-erb beta/BD73 are orphan steroid receptors that have no known ligands in the 'classical sense'. These 'orphans' do not activate transcription, but function as dominant transcriptional silencers. The thyroid hormone receptor (TR) and the retinoic acid receptor (RAR) act as transcriptional silencers by binding corepressors (e.g. N-CoR/RIP13 and SMRT/TRAC-2) in the absence of ligands. The molecular basis ... [more]
Nucleic Acids Res. Nov. 15, 1996; 24(22);4379-86 [Pubmed: 8948627]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR1D1 NCOR1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID