BAIT
PLAT
T-PA, TPA
plasminogen activator, tissue
GO Process (5)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP1
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
GO Process (14)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation.
The low-density lipoprotein (LDL) receptor-related protein (LRP) is a multifunctional endocytic receptor that is expressed abundantly in neurons of the CNS. Both LRP and several of its ligands, including tissue plasminogen activator (tPA), apolipoprotein E/lipoproteins, alpha(2)-macroglobulin, and the beta-amyloid precursor protein, have been implicated in various neuronal functions and in the pathogenesis of Alzheimer's disease. It has been reported that ... [more]
J. Neurosci. Jan. 15, 2000; 20(2);542-9 [Pubmed: 10632583]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID