BAIT
CD14
CD14 molecule
GO Process (17)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- apoptotic process [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular response to lipopolysaccharide [IDA]
- cellular response to lipoteichoic acid [IDA]
- innate immune response [TAS]
- phagocytosis [TAS]
- positive regulation of tumor necrosis factor production [IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LBP
BPIFD2
lipopolysaccharide binding protein
GO Process (22)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- acute-phase response [IEP, ISS]
- cellular defense response [ISS]
- cellular response to lipopolysaccharide [IDA]
- cellular response to lipoteichoic acid [IDA]
- defense response to Gram-negative bacterium [IDA, ISS]
- defense response to Gram-positive bacterium [IDA]
- detection of molecule of bacterial origin [IDA]
- innate immune response [IC, ISS, TAS]
- lipopolysaccharide transport [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage activation involved in immune response [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- opsonization [IC, ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage activation [IDA]
- positive regulation of respiratory burst involved in inflammatory response [ISS]
- positive regulation of toll-like receptor 4 signaling pathway [IDA]
- positive regulation of tumor necrosis factor production [IDA, ISS]
- response to lipopolysaccharide [IDA]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
LPS-dependent interaction of Mac-2-binding protein with immobilized CD14.
CD14 is a glycosylphosphatidyl-inositol (GPI)-linked, 55 kDa protein that binds bacterial lipopolysaccharide (LPS, endotoxin) and plays a key role in mediating cellular responses to this potent inflammatory stimulus. Binding of LPS to CD14 is facilitated by serum proteins such as LPS binding protein (LBP). To determine if there are additional plasma proteins that bind to CD14, plasma was passed over ... [more]
J. Inflamm. Jan. 01, 1995; 45(2);115-25 [Pubmed: 7583357]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID