SORBS1
Gene Ontology Biological Process
- cell-matrix adhesion [TAS]
- cellular response to insulin stimulus [ISS]
- focal adhesion assembly [ISS]
- glucose transport [ISS]
- insulin receptor signaling pathway [ISS]
- muscle contraction [TAS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of glycogen biosynthetic process [ISS]
- positive regulation of lipid biosynthetic process [ISS]
- positive regulation of signal transduction [IC, ISS]
- stress fiber assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
INSM1
Gene Ontology Biological Process
- adrenal chromaffin cell differentiation [ISS]
- endocrine pancreas development [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- noradrenergic neuron development [ISS]
- norepinephrine biosynthetic process [ISS]
- pancreatic A cell differentiation [ISS]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cell differentiation [ISS]
- positive regulation of neural precursor cell proliferation [ISS]
- regulation of gene expression [ISS]
- regulation of protein complex assembly [IDA]
- sympathetic ganglion development [ISS]
- transdifferentiation [IDA]
- type B pancreatic cell differentiation [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- cyclin binding [IPI]
- histone deacetylase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- core promoter binding [IDA]
- cyclin binding [IPI]
- histone deacetylase binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.
Here we describe the isolation and characterization of the mouse homolog of the human zinc-finger transcription factor INSM1 (IA-1) and identify an interacting protein. A 2.9-kb cDNA with an open reading frame of 1563 nucleotides, corresponding to a translated protein of 521 amino acids, was isolated from a mouse beta TC-1 cDNA library. Mouse INSM1 was found to be 86% ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SORBS1 INSM1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| SORBS1 INSM1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID