BAIT
SNTA1
LQT12, SNT1, TACIP1, dJ1187J4.5
syntrophin, alpha 1
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NOS1
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
nitric oxide synthase 1 (neuronal)
GO Process (30)
GO Function (14)
GO Component (11)
Gene Ontology Biological Process
- arginine catabolic process [IC]
- blood coagulation [TAS]
- cellular response to growth factor stimulus [ISS]
- exogenous drug catabolic process [ISS]
- interaction with host [TAS]
- multicellular organismal response to stress [IMP]
- myoblast fusion [TAS]
- negative regulation of blood pressure [IBA]
- negative regulation of calcium ion transport [ISS]
- negative regulation of calcium ion transport into cytosol [TAS]
- negative regulation of hydrolase activity [ISS]
- negative regulation of potassium ion transport [ISS]
- negative regulation of serotonin uptake [ISS]
- neurotransmitter biosynthetic process [TAS]
- nitric oxide biosynthetic process [IBA, ISS]
- nitric oxide mediated signal transduction [IBA]
- peptidyl-cysteine S-nitrosylation [ISS]
- phagosome maturation [TAS]
- positive regulation of guanylate cyclase activity [IBA]
- positive regulation of histone acetylation [ISS]
- positive regulation of sodium ion transmembrane transport [ISS]
- positive regulation of the force of heart contraction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of vasodilation [IDA, IMP]
- regulation of cardiac muscle contraction [TAS]
- regulation of sodium ion transport [ISS]
- response to heat [IDA]
- response to hypoxia [IEP]
- striated muscle contraction [ISS]
Gene Ontology Molecular Function- FMN binding [ISS]
- NADP binding [ISS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [TAS]
- cadmium ion binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- ion channel binding [ISS]
- nitric-oxide synthase activity [IBA, ISS]
- oxidoreductase activity [IBA]
- protein binding [IPI]
- scaffold protein binding [ISS]
- sodium channel regulator activity [ISS]
- tetrahydrobiopterin binding [NAS]
- FMN binding [ISS]
- NADP binding [ISS]
- NADPH-hemoprotein reductase activity [IBA]
- arginine binding [TAS]
- cadmium ion binding [ISS]
- flavin adenine dinucleotide binding [ISS]
- heme binding [ISS]
- ion channel binding [ISS]
- nitric-oxide synthase activity [IBA, ISS]
- oxidoreductase activity [IBA]
- protein binding [IPI]
- scaffold protein binding [ISS]
- sodium channel regulator activity [ISS]
- tetrahydrobiopterin binding [NAS]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.
Syntrophins are cytoplasmic peripheral membrane proteins of the dystrophin-associated protein complex (DAPC). Three syntrophin isoforms, alpha1, beta1, and beta2, are encoded by distinct genes. Each contains two pleckstrin homology (PH) domains, a syntrophin-unique (SU) domain, and a PDZ domain. The name PDZ comes from the first three proteins found to contain repeats of this domain (PSD-95, Drosophila discs large protein, ... [more]
J. Neurosci. Jan. 01, 1998; 18(1);128-37 [Pubmed: 9412493]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NOS1 SNTA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3036557 |
Curated By
- BioGRID