BAIT
ATG10
APG10, APG10L, PP12616
autophagy related 10
GO Process (5)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CUL3
CUL-3, PHA2E
cullin 3
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.
Autophagosome formation requires multiple autophagy-related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including the LC3 lipidation machinery. To address this unexpected result, we performed genome-wide CRISPR screens identifying genes required for NBR1 flux in ATG7KO cells. We find that ATG7-independent autophagy still requires ... [more]
EMBO J Dec. 15, 2019; 39(24);e104948 [Pubmed: 33226137]
Throughput
- High Throughput
Ontology Terms
- autophagy (GO:0006914)
Additional Notes
- CRISPR GI screen
- Cell Line:K-562 (BTO:0000664)
- Experimental Setup: Timecourse; fluorescent ratio read-out as autophagy reporter
- Library:Brunello (ADDGENE:73179)
- Significance Threshold: -0.5>Beta Score>0.5
Curated By
- BioGRID