BAIT
HOMER1
HOMER1F, Vesl-1
homer homolog 1 (Drosophila)
GO Process (14)
GO Function (9)
GO Component (14)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IDA]
- behavioral response to cocaine [ISO]
- chemical homeostasis within a tissue [ISO]
- circadian rhythm [IEP]
- positive regulation of calcium ion transport [ISO]
- protein localization to synapse [IDA]
- regulation of calcium ion import [ISO]
- regulation of cation channel activity [ISO]
- regulation of store-operated calcium entry [IBA, ISO]
- response to calcium ion [ISO]
- response to cocaine [IEP]
- response to nicotine [IEP]
- skeletal muscle contraction [ISO]
- skeletal muscle fiber development [ISO]
Gene Ontology Molecular Function- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
- G-protein coupled glutamate receptor binding [IPI]
- identical protein binding [IPI]
- ion channel binding [ISO]
- protein binding [IPI]
- protein complex scaffold [IPI]
- protein heterodimerization activity [IPI]
- receptor binding [IDA]
- scaffold protein binding [IPI]
- type 5 metabotropic glutamate receptor binding [IPI]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SHANK3
Prosap2
SH3 and multiple ankyrin repeat domains 3
GO Process (33)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- N-methyl-D-aspartate receptor clustering [ISO, ISS]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISO, ISS]
- brain morphogenesis [ISO, ISS]
- dendritic spine morphogenesis [ISO, ISS]
- embryonic epithelial tube formation [ISO]
- guanylate kinase-associated protein clustering [ISO, ISS]
- learning [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- memory [ISO, ISS]
- negative regulation of actin filament bundle assembly [ISO, ISS]
- negative regulation of cell volume [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- positive regulation of dendritic spine development [ISO, ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO, ISS]
- positive regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- positive regulation of synapse structural plasticity [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density assembly [ISO, ISS]
- protein oligomerization [IDA]
- regulation of behavioral fear response [ISO, ISS]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of long term synaptic depression [ISO, ISS]
- regulation of long-term synaptic potentiation [ISO, ISS]
- social behavior [ISO, ISS]
- striatal medium spiny neuron differentiation [ISO, ISS]
- synapse assembly [ISO, ISS]
- vocal learning [ISO]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins.
Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor-associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate receptors and inositol trisphosphate receptors, thereby coupling these receptors ... [more]
Neuron Jul. 01, 1999; 23(3);583-92 [Pubmed: 10433269]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOMER1 SHANK3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID