BAIT
FXR1
FXR1P
fragile X mental retardation, autosomal homolog 1
GO Process (2)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CAPN3
CANP3, CANPL3, LGMD2, LGMD2A, nCL-1, p94
calpain 3, (p94)
GO Process (25)
GO Function (12)
GO Component (9)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular response to calcium ion [ISS]
- cellular response to salt stress [ISS]
- muscle cell cellular homeostasis [TAS]
- muscle organ development [TAS]
- muscle structure development [ISS]
- myofibril assembly [ISS, TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of proteolysis [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of satellite cell activation involved in skeletal muscle regeneration [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [ISS]
- protein localization to membrane [ISS]
- proteolysis [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of catalytic activity [IDA]
- response to calcium ion [ISS]
- response to muscle activity [ISS]
- sarcomere organization [ISS]
- self proteolysis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID