KIT
Gene Ontology Biological Process
- Fc receptor signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- Kit signaling pathway [IDA]
- T cell differentiation [ISS]
- actin cytoskeleton reorganization [IDA]
- activation of MAPK activity [IDA]
- cell chemotaxis [IDA]
- cytokine-mediated signaling pathway [IDA]
- dendritic cell cytokine production [ISS]
- detection of mechanical stimulus involved in sensory perception of sound [ISS]
- digestive tract development [ISS]
- embryonic hemopoiesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- erythrocyte differentiation [ISS]
- erythropoietin-mediated signaling pathway [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [TAS]
- immature B cell differentiation [ISS]
- inflammatory response [ISS]
- innate immune response [TAS]
- lamellipodium assembly [ISS]
- male gonad development [IEP]
- mast cell chemotaxis [IDA]
- mast cell cytokine production [IDA]
- mast cell degranulation [IMP]
- mast cell differentiation [ISS, TAS]
- mast cell proliferation [TAS]
- megakaryocyte development [ISS]
- melanocyte adhesion [ISS]
- melanocyte differentiation [ISS, TAS]
- melanocyte migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- ovarian follicle development [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- pigmentation [ISS]
- positive regulation of JAK-STAT cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell proliferation [TAS]
- regulation of cell shape [ISS]
- signal transduction [TAS]
- signal transduction by phosphorylation [TAS]
- spermatogenesis [ISS, TAS]
- stem cell differentiation [ISS]
- stem cell maintenance [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MPDZ
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity.
We have identified the multiple PDZ domain containing protein (MUPP-1 or MPDZ) as a novel binding partner of the human c-Kit. c-Kit binds specifically to the 10th PDZ domain of MUPP-1 via its C-terminal sequence. Furthermore, a kinase negative-mutant receptor interacted more strongly with MUPP-1 than the wild-type c-Kit. Strikingly, a constitutively activated c-Kit (D816V-Kit) did not bind to MUPP-1, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MPDZ KIT | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| KIT MPDZ | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID