BAIT
TSC1
LAM, TSC
tuberous sclerosis 1
GO Process (17)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell cycle arrest [TAS]
- cell-matrix adhesion [IMP]
- insulin receptor signaling pathway [TAS]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- protein stabilization [IDA]
- rRNA export from nucleus [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [IMP]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of stress fiber assembly [IDA]
- regulation of translation [IDA]
- response to insulin [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BCL11A
BCL11A-L, BCL11A-S, BCL11A-XL, BCL11a-M, CTIP1, EVI9, HBFQTL5, ZNF856
B-cell CLL/lymphoma 11A (zinc finger protein)
GO Process (11)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- negative regulation of axon extension [ISS]
- negative regulation of collateral sprouting [IMP]
- negative regulation of dendrite development [IMP]
- negative regulation of neuron projection development [IDA]
- negative regulation of protein homooligomerization [IC]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of collateral sprouting [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- protein sumoylation [ISS]
- regulation of dendrite development [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [TAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Sci Transl Med Jun. 08, 2011; 3(86);86ra49 [Pubmed: 21653829]
Throughput
- High Throughput
Curated By
- BioGRID