TSC1
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell cycle arrest [TAS]
- cell-matrix adhesion [IMP]
- insulin receptor signaling pathway [TAS]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- protein stabilization [IDA]
- rRNA export from nucleus [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [IMP]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of stress fiber assembly [IDA]
- regulation of translation [IDA]
- response to insulin [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NINL
Gene Ontology Biological Process
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome reveals converging molecular pathways among autism disorders.
To uncover shared pathogenic mechanisms among the highly heterogeneous autism spectrum disorders (ASDs), we developed a protein interaction network that identified hundreds of new interactions among proteins encoded by ASD-associated genes. We discovered unexpectedly high connectivity between SHANK and TSC1, previously implicated in syndromic autism, suggesting that common molecular pathways underlie autistic phenotypes in distinct syndromes. ASD patients were more ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NINL TSC1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID