BAIT
DDX39A
BAT1, BAT1L, DDX39, DDXL, URH49
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
ANXA1
ANX1, LPC1, RP11-71A24.1
annexin A1
GO Process (12)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- alpha-beta T cell differentiation [ISS]
- cellular component movement [TAS]
- cellular response to glucocorticoid stimulus [IDA]
- inflammatory response [TAS]
- keratinocyte differentiation [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of interleukin-8 secretion [IMP]
- neutrophil clearance [IMP]
- neutrophil homeostasis [IMP]
- peptide cross-linking [IDA]
- positive regulation of vesicle fusion [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.
The RNA helicase DDX39A plays an important role in the RNA splicing/export process. In our study, human DDX39A facilitated RNA virus escape from innate immunity to promote virus proliferation by trapping TRAF3, TRAF6, and MAVS mRNAs in the HEK293T cell nucleus. DDX39A was a target for SUMOylation. SUMO1, 2, and 3 modifications were found on immunoprecipitated DDX39A. However, only the ... [more]
J Immunol Dec. 01, 2019; 205(1);168-180 [Pubmed: 32393512]
Quantitative Score
- 2.109059148 [FoldChange]
Throughput
- High Throughput
Additional Notes
- Affinity capture-RNA was carried out to identify high-confidence protein-RNA interactions with a Fold Change over control immuniprecipitation > 2.0 (Fold change reported here)
Curated By
- BioGRID