BAIT
WDR5
BIG-3, CFAP89, SWD3
WD repeat domain 5
GO Process (6)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GPX1
GPXD, GSHPX1
glutathione peroxidase 1
GO Process (21)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- UV protection [IMP]
- arachidonic acid metabolic process [TAS]
- cell redox homeostasis [IDA]
- cellular response to oxidative stress [NAS]
- glutathione metabolic process [IDA]
- heart contraction [IMP]
- hydrogen peroxide catabolic process [IDA]
- lipoxygenase pathway [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of fibril organization [ISS]
- purine nucleobase metabolic process [TAS]
- purine nucleotide catabolic process [TAS]
- regulation of gene expression, epigenetic [IDA]
- regulation of mammary gland epithelial cell proliferation [IMP]
- regulation of proteasomal protein catabolic process [IDA]
- response to hydrogen peroxide [IMP]
- response to selenium ion [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
BPA modulates the WDR5/TET2 complex to regulate ER? expression in eutopic endometrium and drives the development of endometriosis.
Overexpression of estrogen receptor ? (ER?) in endometrium contributes to endometriosis (EM) pathogenesis. Trimethylation of the H3 lysine (K) 4 (H3K4me3) in promoters is strongly correlated with gene expression. This study aimed to explore the effects of bisphenol A (BPA) exposure on EM development from the perspective of the regulation of ER? expression in eutopic endometrium via the H3K4me3-related epigenetic ... [more]
Environ Pollut Jan. 01, 2021; 268(Pt B);115748 [Pubmed: 33022573]
Quantitative Score
- 59.0 [Mascot Score]
Throughput
- High Throughput
Additional Notes
- Affinity capture-MS was carried out to identify high-confidence protein interactions. Mascot Scores are reported here.
Curated By
- BioGRID