TRAF3
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of type I interferon production [TAS]
- regulation of cytokine production [ISS]
- regulation of defense response to virus [ISS]
- regulation of interferon-beta production [ISS]
- regulation of proteolysis [IMP]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [ISS, TAS]
- tumor necrosis factor-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TLR4
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T-helper 1 type immune response [NAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to mechanical stimulus [IEP]
- defense response to Gram-negative bacterium [IC]
- defense response to bacterium [TAS]
- detection of fungus [NAS]
- detection of lipopolysaccharide [IDA]
- immune response [TAS]
- innate immune response [TAS]
- intestinal epithelial structure maintenance [ISS]
- lipopolysaccharide-mediated signaling pathway [IDA, IGI]
- macrophage activation [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of interferon-gamma production [ISS]
- negative regulation of interleukin-17 production [ISS]
- negative regulation of interleukin-23 production [ISS]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of osteoclast differentiation [NAS]
- negative regulation of tumor necrosis factor production [ISS]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha production [ISS]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 production [ISS]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of platelet activation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of tumor necrosis factor production [ISS]
- response to lipopolysaccharide [IC, IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway.
Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short average survival time. No effective treatment is currently available for malignant ascites. In this study, the effects of lentinan (LNT)-functionalized selenium nanoparticles (Selene) on malignant ascites were evaluated. Furthermore, the mechanism of Selene targeting mitochondria of tumor cells were also investigated. Methods: Selene were synthesized and characterized ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TLR4 TRAF3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 594274 | |
| TLR4 TRAF3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TRAF3 TLR4 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
| TLR4 TRAF3 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3023371 |
Curated By
- BioGRID