DRD2
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- Wnt signaling pathway [ISO]
- acid secretion [ISO]
- activation of protein kinase activity [ISO]
- adenohypophysis development [IMP]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA, IGI, IMP, ISO]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISO]
- adult behavior [IMP]
- adult walking behavior [IMP]
- arachidonic acid secretion [ISO]
- associative learning [IMP]
- auditory behavior [ISO]
- axonogenesis [IMP]
- behavioral response to cocaine [IMP]
- behavioral response to ethanol [IMP]
- branching morphogenesis of a nerve [IMP]
- cerebral cortex GABAergic interneuron migration [IMP]
- circadian regulation of gene expression [IMP]
- dopamine metabolic process [IMP]
- dopamine receptor signaling pathway [IGI, ISO]
- feeding behavior [IGI]
- forebrain development [ISO]
- grooming behavior [IMP]
- intracellular signal transduction [ISO]
- locomotory behavior [IGI, IMP, ISO]
- long-term memory [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of blood pressure [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of circadian sleep/wake cycle, sleep [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- negative regulation of dopamine receptor signaling pathway [IGI, IMP]
- negative regulation of dopamine secretion [ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of protein secretion [ISO]
- negative regulation of synaptic transmission, glutamatergic [IMP]
- negative regulation of voltage-gated calcium channel activity [ISO]
- neurological system process involved in regulation of systemic arterial blood pressure [IMP]
- neuron-neuron synaptic transmission [IMP]
- peristalsis [IGI, IMP]
- phosphatidylinositol metabolic process [ISO]
- phospholipase C-activating dopamine receptor signaling pathway [IDA, IGI, ISO]
- pigmentation [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of G-protein coupled receptor protein signaling pathway [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of dopamine uptake involved in synaptic transmission [IMP]
- positive regulation of growth hormone secretion [IMP]
- positive regulation of long-term synaptic potentiation [ISO]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of neuroblast proliferation [IDA]
- positive regulation of receptor internalization [ISO]
- positive regulation of renal sodium excretion [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of urine volume [IMP]
- prepulse inhibition [IMP]
- protein localization [IMP]
- regulation of MAPK cascade [ISO]
- regulation of cAMP metabolic process [ISO]
- regulation of dopamine secretion [IMP]
- regulation of dopamine uptake involved in synaptic transmission [IMP]
- regulation of heart rate [IMP]
- regulation of locomotion involved in locomotory behavior [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of potassium ion transport [IMP, ISO]
- regulation of sodium ion transport [IMP]
- regulation of synapse structural plasticity [ISO]
- regulation of synaptic transmission [IMP, ISO]
- regulation of synaptic transmission, GABAergic [IGI, IMP]
- release of sequestered calcium ion into cytosol [ISO]
- response to amphetamine [IGI, IMP]
- response to cocaine [IDA, IMP]
- response to drug [IDA, IMP, ISO]
- response to histamine [ISO]
- response to hypoxia [ISO]
- response to light stimulus [IMP]
- response to morphine [IMP]
- sensory perception of smell [IMP]
- startle response [IMP]
- synaptic transmission [IDA]
- synaptic transmission, dopaminergic [ISO]
- temperature homeostasis [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- G-protein coupled receptor activity [IDA]
- dopamine binding [IDA, ISO]
- dopamine neurotransmitter receptor activity [IDA, ISO]
- dopamine neurotransmitter receptor activity, coupled via Gi/Go [IDA, IMP, ISO]
- drug binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- G-protein coupled receptor activity [IDA]
- dopamine binding [IDA, ISO]
- dopamine neurotransmitter receptor activity [IDA, ISO]
- dopamine neurotransmitter receptor activity, coupled via Gi/Go [IDA, IMP, ISO]
- drug binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
Gene Ontology Cellular Component
- acrosomal vesicle [ISO]
- axon [IDA, ISO]
- axon terminus [ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- dendrite [IDA, ISO]
- dendritic spine [ISO]
- endocytic vesicle [ISO]
- integral component of plasma membrane [ISO]
- lateral plasma membrane [ISO]
- membrane [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- sperm flagellum [ISO]
- synaptic vesicle membrane [ISO]
CHL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Cell adhesion molecule close homolog of L1 binds to the dopamine receptor D2 and inhibits the internalization of its short isoform.
Cell adhesion molecule close homolog of L1 (CHL1) and the dopamine receptor D2 (DRD2) are associated with psychiatric and mental disorders. We here show that DRD2 interacts with CHL1 in mouse brain, as evidenced by co-immunostaining, proximity ligation assay, co-immunoprecipitation, and pull-down assay with recombinant extracellular CHL1 domain fused to Fc (CHL1-Fc). Direct binding of CHL1-Fc to the first extracellular ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHL1 DRD2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DRD2 CHL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CHL1 DRD2 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3025812 | |
| DRD2 CHL1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 3025813 |
Curated By
- BioGRID