SYK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA, ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- adaptive immune response [IBA, ISS]
- blood coagulation [TAS]
- blood vessel morphogenesis [ISS]
- cell proliferation [TAS]
- cellular response to molecule of fungal origin [ISS]
- defense response to bacterium [ISS]
- inflammatory response [IBA]
- innate immune response [IBA, ISS, TAS]
- integrin-mediated signaling pathway [ISS, NAS]
- leukocyte activation involved in immune response [ISS]
- leukocyte cell-cell adhesion [IDA]
- lymph vessel development [ISS]
- macrophage activation involved in immune response [IBA, ISS]
- neutrophil activation involved in immune response [IBA, ISS]
- neutrophil chemotaxis [IDA]
- organ morphogenesis [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- platelet activation [TAS]
- positive regulation of B cell differentiation [IBA]
- positive regulation of alpha-beta T cell proliferation [IBA]
- positive regulation of bone resorption [ISS]
- positive regulation of cell adhesion mediated by integrin [IBA, ISS]
- positive regulation of mast cell degranulation [IBA]
- protein phosphorylation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of arachidonic acid secretion [ISS]
- regulation of neutrophil degranulation [ISS]
- regulation of phagocytosis [ISS]
- regulation of platelet activation [ISS]
- regulation of platelet aggregation [IBA, ISS]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of superoxide anion generation [ISS]
- serotonin secretion by platelet [ISS]
- transcription factor import into nucleus [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PXN
Gene Ontology Biological Process
- cell adhesion [NAS]
- cell junction assembly [TAS]
- cellular response to reactive oxygen species [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- growth hormone receptor signaling pathway [IDA]
- muscle contraction [TAS]
- signal complex assembly [TAS]
- signal transduction [TAS]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Syk activation is required for spreading and H2O2 release in adherent human neutrophils.
Chemoattractant-stimulated polymorphonuclear leukocytes (PMNs) that are adherent to extracellular matrix proteins exhibit a massive, sustained respiratory burst that requires cell spreading. However, the signaling pathways culminating in PMN spreading are not well characterized. Studies showing that protein tyrosine phosphorylation increases with PMN spreading suggest that phosphorylation is critical for this process. In the present study, we observed increased tyrosine phosphorylation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID