A2M
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL10
Gene Ontology Biological Process
- B cell differentiation [NAS]
- B cell proliferation [NAS]
- cell-cell signaling [IC]
- cellular response to lipopolysaccharide [NAS]
- cytoplasmic sequestering of NF-kappaB [NAS]
- hemopoiesis [TAS]
- inflammatory response [IDA]
- leukocyte chemotaxis [TAS]
- negative regulation of B cell proliferation [IDA]
- negative regulation of MHC class II biosynthetic process [TAS]
- negative regulation of T cell proliferation [NAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of interferon-alpha biosynthetic process [NAS]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of B cell apoptotic process [IDA]
- positive regulation of JAK-STAT cascade [IBA]
- positive regulation of cytokine secretion [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- receptor biosynthetic process [IDA]
- regulation of gene expression [IDA]
- regulation of isotype switching [NAS]
- response to glucocorticoid [IDA]
- response to molecule of bacterial origin [IDA]
- type 2 immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interleukin-4 and IL-10 bind covalently to activated human alpha2-macroglobulin by a mechanism that requires Cys949.
Alpha2-macroglobulin (alpha2M) functions as an extracellular carrier of diverse cytokines, including transforming growth factor-beta1 (TGF-beta1), that expresses anti-inflammatory activities. The results presented here demonstrate that interleukin-10 (IL-10) and IL-4, which also regulate the inflammatory response, bind to alpha2M. Unlike TGF-beta, IL-4 and IL-10 bind almost exclusively to the receptor-recognized, or activated, form of alpha2M. Purified IL-4-alpha2M complexes were predominantly covalent ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IL10 A2M | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | High | - | BioGRID | 1504781 |
Curated By
- BioGRID