PLXNB1
Gene Ontology Biological Process
- axon guidance [TAS]
- cell migration [NAS]
- intracellular signal transduction [NAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast proliferation [ISS]
- neuron projection morphogenesis [ISS]
- ossification involved in bone maturation [ISS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- regulation of cell shape [IDA]
- regulation of cytoskeleton organization [IDA]
- semaphorin-plexin signaling pathway [IDA]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARHGEF12
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- apoptotic signaling pathway [TAS]
- axon guidance [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors.
The Rho family GTPase has been implicated in plexin-B1, a receptor for Semaphorin 4D (Sema4D), mediating signal transduction. Rho may also play a function in this signaling pathway as well as Rac, but the mechanisms for Rho regulation are poorly understood. In this study, we have identified two kinds of PDZ domain-containing Rho-specific guanine nucleotide exchange factors (RhoGEFs) as proteins ... [more]
Throughput
- Low Throughput
Additional Notes
- Plexin-B1 also interactions with rat homologs of KIAA0380 and LARG, but they are not identified by name.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARHGEF12 PLXNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID