BAIT
DRD4
D4DR
dopamine receptor D4
GO Process (24)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- adult locomotory behavior [ISS]
- arachidonic acid secretion [IDA]
- behavioral fear response [NAS]
- behavioral response to cocaine [ISS]
- behavioral response to ethanol [TAS]
- cellular calcium ion homeostasis [IC]
- dopamine metabolic process [IC]
- dopamine receptor signaling pathway [IDA]
- fear response [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of cAMP biosynthetic process [IDA]
- negative regulation of protein secretion [IDA]
- negative regulation of voltage-gated calcium channel activity [IDA]
- positive regulation of dopamine uptake involved in synaptic transmission [IC]
- positive regulation of kinase activity [IDA]
- positive regulation of sodium:proton antiporter activity [IDA]
- regulation of circadian rhythm [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of inhibitory postsynaptic membrane potential [ISS]
- response to amphetamine [ISS]
- response to histamine [IDA]
- social behavior [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ATM
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
ATM serine/threonine kinase
GO Process (23)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- DNA damage induced protein phosphorylation [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA repair [TAS]
- cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to gamma radiation [IDA]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- histone mRNA catabolic process [IDA]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of B cell proliferation [IMP]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IMP]
- pre-B cell allelic exclusion [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- reciprocal meiotic recombination [TAS]
- replicative senescence [IMP]
- response to ionizing radiation [IDA]
- signal transduction [TAS]
- signal transduction involved in mitotic G2 DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.956701231 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.956701231, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID