SCIN
Gene Ontology Biological Process
- actin filament severing [IMP]
- actin nucleation [ISS]
- calcium ion-dependent exocytosis [ISS]
- negative regulation of cell proliferation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of secretion [ISS]
- regulation of chondrocyte differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ACTA1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis.
Scinderin (Sc), a Ca(2+)-regulated actin-binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F-actin dynamics during secretion. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID