BAIT
SLC11A2
DCT1, DMT1, NRAMP2, OK/SW-cl.20
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
GO Process (22)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cadmium ion transmembrane transport [IDA]
- cation transmembrane transport [IGI]
- cellular iron ion homeostasis [TAS]
- cellular response to oxidative stress [IDA]
- cobalt ion transport [IDA]
- copper ion transmembrane transport [IDA]
- copper ion transport [IDA]
- detection of oxygen [IEP]
- ferrous iron import [IDA]
- ferrous iron transport [IDA]
- lead ion transport [IDA]
- manganese ion transmembrane transport [IDA]
- manganese ion transport [IDA]
- multicellular organismal iron ion homeostasis [IMP]
- nickel cation transmembrane transport [IDA]
- nickel cation transport [IDA]
- response to hypoxia [IEP]
- response to iron ion [IEP]
- transmembrane transport [TAS]
- vanadium ion transport [IDA]
- zinc ion transmembrane transport [IDA]
Gene Ontology Molecular Function- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal part of cell [IDA]
- cell surface [IDA]
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- early endosome [IDA]
- late endosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane [IDA]
- nucleus [IDA]
- paraferritin complex [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP, TAS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
- vacuole [IMP]
Homo sapiens
PREY
ATP2B4
ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x
ATPase, Ca++ transporting, plasma membrane 4
GO Process (23)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- blood coagulation [TAS]
- calcium ion homeostasis [IC]
- calcium ion import across plasma membrane [IC]
- calcium ion transmembrane transport [IMP]
- cellular calcium ion homeostasis [IDA]
- cellular response to epinephrine stimulus [IDA]
- ion transmembrane transport [TAS]
- negative regulation of adrenergic receptor signaling pathway involved in heart process [IDA]
- negative regulation of arginine catabolic process [IDA]
- negative regulation of calcineurin-NFAT signaling cascade [IDA]
- negative regulation of cardiac muscle hypertrophy in response to stress [IMP]
- negative regulation of citrulline biosynthetic process [IDA]
- negative regulation of nitric oxide biosynthetic process [IDA]
- negative regulation of nitric oxide mediated signal transduction [IDA]
- negative regulation of nitric-oxide synthase activity [IDA]
- negative regulation of peptidyl-cysteine S-nitrosylation [NAS]
- negative regulation of the force of heart contraction [IDA]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- regulation of sodium ion transmembrane transport [IC]
- regulation of transcription from RNA polymerase II promoter [IMP]
- response to hydrostatic pressure [IMP]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.977401412 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.977401412, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC11A2 ATP2B4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.6679 | BioGRID | 3808633 | |
| SLC11A2 ATP2B4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9754 | BioGRID | 3274907 |
Curated By
- BioGRID