BAIT
CFLAR
CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
CASP8 and FADD-like apoptosis regulator
GO Process (16)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- apoptotic process [IMP, TAS]
- apoptotic signaling pathway [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of extrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of myoblast fusion [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [ISS]
- positive regulation of catalytic activity [IDA]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- regulation of necroptotic process [IDA]
- regulation of satellite cell proliferation [ISS]
- skeletal muscle atrophy [ISS]
- skeletal muscle tissue development [ISS]
- skeletal muscle tissue regeneration [ISS]
- skeletal myofibril assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NOL3
ARC, FCM, MYP, NOP, NOP30
nucleolar protein 3 (apoptosis repressor with CARD domain)
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
We have identified and characterized ARC, apoptosis repressor with caspase recruitment domain (CARD). Sequence analysis revealed that ARC contains an N-terminal CARD fused to a C-terminal region rich in proline/glutamic acid residues. The CARD domain of ARC exhibited significant homology to the prodomains of apical caspases and the CARDs present in the cell death regulators Apaf-1 and RAIDD. Immunoprecipitation analysis ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 28, 1998; 95(9);5156-60 [Pubmed: 9560245]
Throughput
- Low Throughput
Ontology Terms
- phenotype: apoptosis (APO:0000155)
Curated By
- BioGRID