A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.

Koseki T, Inohara N, Chen S, Nunez G

We have identified and characterized ARC, apoptosis repressor with caspase recruitment domain (CARD). Sequence analysis revealed that ARC contains an N-terminal CARD fused to a C-terminal region rich in proline/glutamic acid residues. The CARD domain of ARC exhibited significant homology to the prodomains of apical caspases and the CARDs present in the cell death regulators Apaf-1 and RAIDD. Immunoprecipitation analysis ... [more]

Proc. Natl. Acad. Sci. U.S.A. Apr. 28, 1998; 95(9);5156-60 [Pubmed: 9560245]

Throughput

Low Throughput

Ontology Terms

phenotype: apoptosis (APO:0000155)

Additional Notes

TNFRSF6 is FAS

Curated By

BioGRID

Interaction Summary

FAS

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [IPI]kinase binding [IPI]protein binding [IPI]receptor activity [NAS]signal transducer activity [TAS]

Gene Ontology Cellular Component

NOL3

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [TAS]identical protein binding [IPI]protein binding [IPI]