POR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYP2E1
Gene Ontology Biological Process
- drug metabolic process [IDA, IMP]
- epoxygenase P450 pathway [IBA]
- exogenous drug catabolic process [IBA]
- heterocycle metabolic process [IDA]
- monoterpenoid metabolic process [IDA]
- oxidation-reduction process [IDA]
- small molecule metabolic process [TAS]
- steroid metabolic process [IMP]
- xenobiotic metabolic process [IBA, TAS]
Gene Ontology Molecular Function- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [IPI]
- heme binding [IDA]
- monooxygenase activity [IDA]
- oxidoreductase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [TAS]
- steroid hydroxylase activity [IBA]
- arachidonic acid epoxygenase activity [IBA]
- enzyme binding [IPI]
- heme binding [IDA]
- monooxygenase activity [IDA]
- oxidoreductase activity [IDA]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [TAS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [IBA]
- oxygen binding [TAS]
- steroid hydroxylase activity [IBA]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems.
The reduction of ferric cytochrome P450 (P450) to ferrous is the first chemical step in almost all P450 reactions, and many characteristics of this step have been reported. Reduction kinetics of rabbit and human P450s were measured in a variety of systems. As reported earlier, P450 reduction is biphasic in microsomes and some purified P450 systems. However, this is not ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CYP2E1 POR | PCA PCA A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay. | Low | - | BioGRID | 1870215 | |
| POR CYP2E1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| CYP2E1 POR | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 833264 |
Curated By
- BioGRID