HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ARNTL
Gene Ontology Biological Process
- circadian regulation of gene expression [IDA, ISS]
- circadian rhythm [TAS]
- negative regulation of TOR signaling [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of glucocorticoid receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- oxidative stress-induced premature senescence [ISS]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of circadian rhythm [ISS]
- positive regulation of skeletal muscle cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISS]
- regulation of cell cycle [ISS]
- regulation of cellular senescence [ISS]
- regulation of hair cycle [IMP]
- regulation of insulin secretion [ISS]
- regulation of neurogenesis [ISS]
- regulation of transcription, DNA-templated [ISS]
- regulation of type B pancreatic cell development [ISS]
- response to redox state [IDA]
- spermatogenesis [ISS]
Gene Ontology Molecular Function- DNA binding [IDA, IGI]
- E-box binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- aryl hydrocarbon receptor binding [IPI]
- core promoter binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
- DNA binding [IDA, IGI]
- E-box binding [IDA]
- Hsp90 protein binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [ISS]
- aryl hydrocarbon receptor binding [IPI]
- core promoter binding [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [ISS]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
In an effort to better understand the mechanism of toxicity of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, we employed an iterative search of human expressed sequence tags to identify novel basic-helix-loop-helix-PAS (bHLH-PAS) proteins that interact with either the Ah receptor (AHR) or the Ah receptor nuclear translocator (ARNT). We characterized five new "members of the PAS superfamily," or MOPs 1-5, that are similar in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID