BAIT
DNAJC14
DNAJ, DRIP78, HDJ3, LIP6, hCG_2016179
DnaJ (Hsp40) homolog, subfamily C, member 14
GO Process (0)
GO Function (0)
GO Component (4)
Gene Ontology Cellular Component
Homo sapiens
PREY
DRD1
DADR, DRD1A
dopamine receptor D1
GO Process (22)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IDA]
- activation of adenylate cyclase activity [IDA]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- cellular response to catecholamine stimulus [IDA]
- cerebral cortex GABAergic interneuron migration [ISS]
- dopamine metabolic process [IC]
- mating behavior [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IDA, IGI]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of potassium ion transport [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- prepulse inhibition [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to drug [ISS]
- synapse assembly [ISS]
- transmission of nerve impulse [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein.
Many structural determinants for G protein-coupled receptor (GPCR) functions have been defined, but little is known concerning the regulation of their transport from the endoplasmic reticulum (ER) to the cell surface. Here we show that a carboxy-terminal hydrophobic motif, FxxxFxxxF, which is highly conserved among GPCRs, functions independently as an ER-export signal for the dopamine D1 receptor. A newly identified ... [more]
Nat. Cell Biol. May. 01, 2001; 3(5);492-8 [Pubmed: 11331877]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DNAJC14 DRD1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID