DRD1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IDA]
- activation of adenylate cyclase activity [IDA]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adult walking behavior [ISS]
- cellular response to catecholamine stimulus [IDA]
- cerebral cortex GABAergic interneuron migration [ISS]
- dopamine metabolic process [IC]
- mating behavior [ISS]
- phospholipase C-activating dopamine receptor signaling pathway [IDA, IGI]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of cell migration [ISS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]
- positive regulation of potassium ion transport [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- prepulse inhibition [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to drug [ISS]
- synapse assembly [ISS]
- transmission of nerve impulse [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
COPG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus.
Truncations at the carboxyl termini of G protein-coupled receptors result in defective receptor biogenesis and comprise a number of inherited disorders. In order to evaluate the structural role of the C-terminus in G protein-coupled receptor biogenesis, we generated a series of deletion and substitution mutations in the dopamine D1 receptor and visualized receptor subcellular localization by fusion to a green ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DRD1 COPG1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID