BAIT
SRF
MCM1
serum response factor (c-fos serum response element-binding transcription factor)
GO Process (23)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
- angiogenesis involved in wound healing [TAS]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular senescence [IMP]
- heart development [ISS]
- heart looping [ISS]
- mRNA transcription from RNA polymerase II promoter [ISS]
- muscle cell cellular homeostasis [ISS]
- negative regulation of beta-amyloid clearance [IMP]
- neuron development [TAS]
- positive regulation of cell differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle contraction [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IGI]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription via serum response element binding [IDA]
- regulation of smooth muscle cell differentiation [TAS]
- response to cytokine [IMP, NAS]
- response to hormone [IDA]
- response to hypoxia [IEP]
- response to toxic substance [TAS]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- serum response element binding [IDA]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- serum response element binding [IDA]
- transcription factor binding [IPI]
Homo sapiens
PREY
CD63
LAMP-3, ME491, MLA1, OMA81H, TSPAN30
CD63 molecule
GO Process (12)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell migration [IMP]
- cell-matrix adhesion [IMP]
- cellular protein localization [IDA]
- endosome to melanosome transport [IMP]
- pigment granule maturation [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of integrin-mediated signaling pathway [IMP]
- positive regulation of receptor internalization [IMP]
- regulation of rubidium ion transport [IDA]
- regulation of vascular endothelial growth factor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- endosome lumen [IDA]
- endosome membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intrinsic component of plasma membrane [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- multivesicular body, internal vesicle [IDA]
- plasma membrane [TAS]
- platelet dense granule membrane [TAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction of ATF6 and serum response factor.
Serum response factor (SRF) is a transcription factor which binds to the serum response element (SRE) in the c-fos promoter. It is required for regulated expression of the c-fos gene as well as other immediate-early genes and some tissue-specific genes. To better understand the regulation of SRF, we used a yeast interaction assay to screen a human HeLa cell cDNA ... [more]
Mol. Cell. Biol. Sep. 01, 1997; 17(9);4957-66 [Pubmed: 9271374]
Throughput
- Low Throughput
Curated By
- BioGRID