BAIT
ST14
ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
suppression of tumorigenicity 14 (colon carcinoma)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SULF1
HSULF-1, SULF-1
sulfatase 1
GO Process (21)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- bone development [ISS]
- cartilage development [ISS]
- chondrocyte development [ISS]
- embryonic skeletal system development [ISS]
- esophagus smooth muscle contraction [ISS]
- glial cell-derived neurotrophic factor receptor signaling pathway [ISS]
- glomerular basement membrane development [ISS]
- glomerular filtration [ISS]
- heparan sulfate proteoglycan metabolic process [IDA, NAS]
- innervation [ISS]
- kidney development [ISS]
- negative regulation of angiogenesis [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP, ISS]
- negative regulation of prostatic bud formation [ISS]
- positive regulation of BMP signaling pathway [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation vascular endothelial growth factor production [ISS]
- regulation of fibroblast growth factor receptor signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.875224663 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.875224663, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID