BAIT
SRRT
ARS2, ASR2, serrate
serrate, RNA effector molecule
GO Process (5)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
AKR1C2
AKR1C-pseudo, BABP, DD, DD-2, DD/BABP, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
aldo-keto reductase family 1, member C2
GO Process (13)
GO Function (7)
GO Component (0)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- cellular response to jasmonic acid stimulus [IDA]
- cellular response to prostaglandin D stimulus [IDA]
- daunorubicin metabolic process [IMP]
- digestion [IDA]
- doxorubicin metabolic process [IMP]
- epithelial cell differentiation [IEP]
- oxidation-reduction process [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- progesterone metabolic process [IDA]
- prostaglandin metabolic process [IDA]
- steroid metabolic process [IDA]
Gene Ontology Molecular Function- alditol:NADP+ 1-oxidoreductase activity [IDA]
- bile acid binding [IDA]
- carboxylic acid binding [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [IDA]
- alditol:NADP+ 1-oxidoreductase activity [IDA]
- bile acid binding [IDA]
- carboxylic acid binding [IDA]
- ketosteroid monooxygenase activity [IDA]
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [IDA]
- phenanthrene 9,10-monooxygenase activity [IDA]
- trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999972078 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999972078, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID