BAIT
PDGFRB
CD140B, IBGC4, IMF1, JTK12, PDGFR, PDGFR-1, PDGFR1
platelet-derived growth factor receptor, beta polypeptide
GO Process (42)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- aorta morphogenesis [ISS]
- cardiac myofibril assembly [ISS]
- cell chemotaxis [IDA]
- cell migration [IMP]
- cell migration involved in coronary angiogenesis [ISS]
- cell migration involved in vasculogenesis [ISS]
- cellular response to platelet-derived growth factor stimulus [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- metanephric glomerular capillary formation [ISS]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol metabolic process [IMP]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISS]
- positive regulation of MAP kinase activity [ISS]
- positive regulation of calcium ion import [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phosphoprotein phosphatase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [ISS]
- positive regulation of smooth muscle cell migration [IMP, ISS]
- positive regulation of smooth muscle cell proliferation [IMP, ISS]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton organization [ISS]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- smooth muscle cell chemotaxis [ISS]
Gene Ontology Molecular Function- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
- platelet activating factor receptor activity [TAS]
- platelet-derived growth factor beta-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- platelet-derived growth factor-activated receptor activity [TAS]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA]
- receptor binding [IPI]
- vascular endothelial growth factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
HSP90AA1
EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
heat shock protein 90kDa alpha (cytosolic), class A member 1
GO Process (16)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- axon guidance [TAS]
- chaperone-mediated protein complex assembly [IDA]
- innate immune response [TAS]
- mitochondrial transport [TAS]
- mitotic cell cycle [TAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric oxide biosynthetic process [ISS]
- protein import into mitochondrial outer membrane [IDA]
- protein refolding [TAS]
- regulation of nitric-oxide synthase activity [TAS]
- response to unfolded protein [NAS]
- signal transduction [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.778998761 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.778998761, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HSP90AA1 PDGFRB | Affinity Capture-Luminescence Affinity Capture-Luminescence An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag. | High | - | BioGRID | - |
Curated By
- BioGRID