SRPRB
Gene Ontology Biological Process
Gene Ontology Cellular Component
HMOX1
Gene Ontology Biological Process
- angiogenesis [TAS]
- cell death [ISS]
- cellular iron ion homeostasis [TAS]
- cellular response to hypoxia [IEP]
- endothelial cell proliferation [TAS]
- erythrocyte homeostasis [IMP]
- excretion [IC]
- heme catabolic process [IDA, TAS]
- heme oxidation [IDA]
- intracellular signal transduction [TAS]
- iron ion homeostasis [IDA, IMP]
- low-density lipoprotein particle clearance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of leukocyte migration [TAS]
- negative regulation of smooth muscle cell proliferation [IDA]
- porphyrin-containing compound metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of chemokine biosynthetic process [TAS]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of vasodilation [IC]
- protein homooligomerization [IDA]
- regulation of angiogenesis [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [ISS]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISS]
- response to hydrogen peroxide [ISS]
- response to nicotine [IDA]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [TAS]
- transmembrane transport [TAS]
- wound healing involved in inflammatory response [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.994819646 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.994819646, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SRPRB HMOX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9972 | BioGRID | 1178243 | |
| SRPRB HMOX1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9902 | BioGRID | 2241088 |
Curated By
- BioGRID