BAIT
LRP1
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
GO Process (14)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FOXF1
ACDMPV, FKHL5, FREAC1
forkhead box F1
GO Process (22)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- blood vessel development [IMP]
- branching involved in open tracheal system development [IMP]
- cardiac left ventricle morphogenesis [IMP]
- digestive tract development [IMP]
- ductus arteriosus closure [IMP]
- embryonic digestive tract morphogenesis [IMP]
- embryonic ectodermal digestive tract morphogenesis [IMP]
- endocardial cushion development [IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- lung development [IMP]
- lung vasculature development [IMP]
- midgut development [IMP]
- morphogenesis of a branching structure [IMP]
- pancreas development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- renal system development [IMP]
- respiratory tube development [IMP]
- transcription from RNA polymerase II promoter [IBA]
- ureter development [IMP]
- venous blood vessel development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- sequence-specific DNA binding [ISS]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.817678809 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.817678809, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID