SUSD4
ECE1
Gene Ontology Biological Process
- bradykinin catabolic process [IDA]
- calcitonin catabolic process [IDA]
- ear development [IMP]
- embryonic digit morphogenesis [IMP]
- endothelin maturation [IDA]
- heart development [IMP]
- hormone catabolic process [IDA]
- peptide hormone processing [IDA]
- positive regulation of receptor recycling [IMP]
- protein processing [IDA]
- regulation of systemic arterial blood pressure by endothelin [IC]
- regulation of vasoconstriction [IC]
- substance P catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Weibel-Palade body [IDA]
- early endosome [IDA]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [IDA]
- intrinsic component of endosome membrane [TAS]
- lysosomal membrane [IDA]
- membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- vesicle [ISS]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.789205509 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.789205509, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SUSD4 ECE1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8247 | BioGRID | 2266482 |
Curated By
- BioGRID