BAIT
E2F1
E2F-1, RBAP1, RBBP3, RBP3
E2F transcription factor 1
GO Process (18)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- G1/S transition of mitotic cell cycle [TAS]
- Notch signaling pathway [TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- mRNA stabilization [IDA]
- mitotic cell cycle [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of G1/S transition of mitotic cell cycle [IMP]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PURA
PUR-ALPHA, PUR1, PURALPHA, hCG_45299
purine-rich element binding protein A
GO Process (4)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1.
Protein-protein interaction can play an important role in the control of several biological events including gene transcription, replication and cell proliferation. E2F-1 is a DNA-binding transcription factor which, upon interaction with its target DNA sequence, induces expression of several S phase specific genes allowing progression of the cell cycle. Evidently, the activity of this protein is modulated by its cellular ... [more]
Oncogene Nov. 04, 1999; 18(46);6398-402 [Pubmed: 10597240]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PURA E2F1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| PURA E2F1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID