TRPV4
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISS]
- actin filament organization [ISS]
- calcium ion import [ISS]
- calcium ion transmembrane transport [TAS]
- calcium ion transport [IDA, NAS]
- cell volume homeostasis [TAS]
- cell-cell junction assembly [ISS]
- cellular calcium ion homeostasis [IDA]
- cellular hypotonic response [ISS]
- cellular response to heat [ISS]
- cellular response to osmotic stress [ISS]
- cortical microtubule organization [ISS]
- ion transmembrane transport [TAS]
- microtubule polymerization [ISS]
- negative regulation of neuron projection development [ISS]
- osmosensory signaling pathway [ISS, TAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of microtubule depolymerization [ISS]
- response to mechanical stimulus [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
YES1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- blood coagulation [TAS]
- cell differentiation [IBA]
- cellular protein modification process [TAS]
- cellular response to peptide hormone stimulus [IBA]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- regulation of cell proliferation [IBA]
- regulation of vascular permeability [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
The recently identified transient receptor potential (TRP) channel family member, TRPV4 (formerly known as OTRPC4, VR-OAC, TRP12, and VRL-2) is activated by hypotonicity. It is highly expressed in the kidney as well as blood-brain barrier-deficient hypothalamic nuclei responsible for systemic osmosensing. Apart from its gating by hypotonicity, little is known about TRPV4 regulation. We observed that hypotonic stress resulted in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID