TRPV4
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISS]
- actin filament organization [ISS]
- calcium ion import [ISS]
- calcium ion transmembrane transport [TAS]
- calcium ion transport [IDA, NAS]
- cell volume homeostasis [TAS]
- cell-cell junction assembly [ISS]
- cellular calcium ion homeostasis [IDA]
- cellular hypotonic response [ISS]
- cellular response to heat [ISS]
- cellular response to osmotic stress [ISS]
- cortical microtubule organization [ISS]
- ion transmembrane transport [TAS]
- microtubule polymerization [ISS]
- negative regulation of neuron projection development [ISS]
- osmosensory signaling pathway [ISS, TAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of microtubule depolymerization [ISS]
- response to mechanical stimulus [TAS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HCK
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cell adhesion [TAS]
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA, TAS]
- innate immune response-activating signal transduction [TAS]
- integrin-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte degranulation [TAS]
- leukocyte migration involved in immune response [TAS]
- lipopolysaccharide-mediated signaling pathway [TAS]
- mesoderm development [TAS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of actin cytoskeleton reorganization [IDA, IMP]
- positive regulation of actin filament polymerization [TAS]
- positive regulation of cell proliferation [IMP]
- protein autophosphorylation [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IMP]
- regulation of defense response to virus by virus [TAS]
- regulation of inflammatory response [TAS]
- regulation of phagocytosis [IMP]
- regulation of podosome assembly [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [IMP]
- respiratory burst after phagocytosis [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
The recently identified transient receptor potential (TRP) channel family member, TRPV4 (formerly known as OTRPC4, VR-OAC, TRP12, and VRL-2) is activated by hypotonicity. It is highly expressed in the kidney as well as blood-brain barrier-deficient hypothalamic nuclei responsible for systemic osmosensing. Apart from its gating by hypotonicity, little is known about TRPV4 regulation. We observed that hypotonic stress resulted in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID