BAIT
NRP1
BDCA4, CD304, NP1, NRP, VEGF165R, RP11-342D11.1
neuropilin 1
GO Process (43)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- angiogenesis [IMP, ISS]
- angiogenesis involved in coronary vascular morphogenesis [ISS]
- artery morphogenesis [ISS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- axonogenesis involved in innervation [ISS]
- cell migration involved in sprouting angiogenesis [ISS]
- cell-cell signaling [TAS]
- cellular response to hepatocyte growth factor stimulus [IMP]
- cellular response to vascular endothelial growth factor stimulus [ISS]
- commissural neuron axon guidance [ISS]
- endothelial cell chemotaxis [IMP]
- endothelial tip cell fate specification [ISS]
- hepatocyte growth factor receptor signaling pathway [IMP]
- nerve development [ISS]
- neural crest cell migration involved in autonomic nervous system development [ISS]
- neuron migration [ISS]
- organ morphogenesis [TAS]
- patterning of blood vessels [ISS]
- platelet-derived growth factor receptor signaling pathway [IMP]
- positive chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of cytokine activity [TAS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of smooth muscle cell migration [TAS]
- protein localization to early endosome [ISS]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of vesicle-mediated transport [TAS]
- retina vasculature morphogenesis in camera-type eye [ISS]
- retinal ganglion cell axon guidance [ISS]
- semaphorin-plexin signaling pathway [NAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
VEGFB
VEGFL, VRF
vascular endothelial growth factor B
GO Process (17)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- blood coagulation [TAS]
- induction of positive chemotaxis [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of neuron apoptotic process [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of mast cell chemotaxis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of vascular permeability [IDA]
- positive regulation of vascular wound healing [IDA]
- vascular endothelial growth factor receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.
Vascular endothelial growth factor B (VEGF-B) is expressed in various tissues, especially strongly in the heart, and binds selectively to one of the VEGF receptors, VEGFR-1. The two splice isoforms, VEGF-B(167) and VEGF-B(186), have identical NH(2)-terminal cystine knot growth factor domains but differ in their COOH-terminal domains which give these forms their distinct biochemical properties. In this study, we show ... [more]
J. Biol. Chem. Jul. 23, 1999; 274(30);21217-22 [Pubmed: 10409677]
Throughput
- Low Throughput
Curated By
- BioGRID