BAIT
UGT1A7
UDPGT, UDPGT 1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7
GO Process (15)
GO Function (8)
GO Component (2)
Gene Ontology Biological Process
- cellular glucuronidation [IDA]
- cellular response to hormone stimulus [IBA]
- coumarin metabolic process [IC]
- drug metabolic process [IC, IDA]
- excretion [IC]
- fatty acid metabolic process [IDA]
- flavone metabolic process [IC]
- flavonoid biosynthetic process [IBA]
- flavonoid glucuronidation [IDA]
- negative regulation of catalytic activity [IDA]
- negative regulation of cellular glucuronidation [IDA]
- negative regulation of fatty acid metabolic process [IDA]
- negative regulation of transferase activity [IDA]
- retinoic acid metabolic process [IC]
- xenobiotic glucuronidation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ST14
ARCI11, HAI, MT-SP1, MTSP1, PRSS14, SNC19, TADG15, TMPRSS14
suppression of tumorigenicity 14 (colon carcinoma)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.753103475 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.753103475, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID