BAIT
IFNG
IFG, IFI
interferon, gamma
GO Process (32)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- adaptive immune response [IBA]
- apoptotic process [IGI]
- cell cycle arrest [IDA]
- cell surface receptor signaling pathway [TAS]
- cellular component movement [TAS]
- cytokine-mediated signaling pathway [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- humoral immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of epithelial cell differentiation [ISS]
- negative regulation of interleukin-17 production [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [IDA]
- positive regulation of fructose 1,6-bisphosphate metabolic process [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-23 production [IDA]
- positive regulation of killing of cells of other organism [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IDA, NAS]
- positive regulation of smooth muscle cell apoptotic process [IDA]
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [IDA]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IDA]
- positive regulation of vitamin D biosynthetic process [IDA]
- protein import into nucleus, translocation [IDA]
- regulation of insulin secretion [IDA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- response to virus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MYO18A
MYSPDZ, SPR210
myosin XVIIIA
GO Process (6)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.977314389 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.977314389, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID