ECSIT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP3K1
Gene Ontology Biological Process
- JNK cascade [IDA]
- MAPK cascade [IBA]
- activation of JNKK activity [ISO]
- activation of JUN kinase activity [IDA]
- activation of MAPKK activity [IBA]
- apoptotic mitochondrial changes [IMP]
- camera-type eye development [IMP]
- epithelial cell morphogenesis [IMP]
- eyelid development in camera-type eye [IMP]
- positive regulation of actin filament polymerization [IMP]
- protein phosphorylation [IBA]
- protein ubiquitination [ISO]
- regulation of cell migration [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
- wound healing [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- JUN kinase kinase activity [IDA]
- JUN kinase kinase kinase activity [ISO]
- MAP kinase kinase kinase activity [IBA, ISO]
- mitogen-activated protein kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- sphingolipid binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- JUN kinase binding [ISO]
- JUN kinase kinase activity [IDA]
- JUN kinase kinase kinase activity [ISO]
- MAP kinase kinase kinase activity [IBA, ISO]
- mitogen-activated protein kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [ISO]
- sphingolipid binding [ISO]
- ubiquitin-protein transferase activity [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.
Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. We report the identification and characterization of a novel intermediate in these signaling pathways that bridges TRAF6 to MEKK-1. This adapter protein, which we have named ECSIT (evolutionarily conserved signaling intermediate in Toll pathways), is specific for the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAP3K1 ECSIT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| MAP3K1 ECSIT | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID