VCAN
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell recognition [TAS]
- central nervous system development [IBA]
- chondroitin sulfate biosynthetic process [TAS]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- dermatan sulfate biosynthetic process [TAS]
- extracellular matrix organization [TAS]
- glial cell migration [IDA]
- glycosaminoglycan metabolic process [TAS]
- multicellular organismal development [TAS]
- osteoblast differentiation [IDA]
- skeletal system development [IBA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PF4
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- blood coagulation [TAS]
- chemokine-mediated signaling pathway [IBA]
- cytokine-mediated signaling pathway [IDA]
- immune response [IBA]
- inflammatory response [IBA]
- leukocyte chemotaxis [IDA]
- negative regulation of MHC class II biosynthetic process [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of cytolysis [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of megakaryocyte differentiation [IDA]
- platelet activation [IDA, TAS]
- platelet degranulation [TAS]
- positive regulation of cAMP metabolic process [IDA]
- positive regulation of cAMP-mediated signaling [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of leukocyte chemotaxis [IBA]
- positive regulation of macrophage derived foam cell differentiation [IDA]
- positive regulation of macrophage differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- regulation of cell proliferation [IDA]
- response to lipopolysaccharide [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Versican interacts with chemokines and modulates cellular responses.
We previously reported that versican, a large chondroitin sulfate proteoglycan, isolated from a renal adenocarcinoma cell line, ACHN, binds L-selectin. Here we report that versican also binds certain chemokines and regulates chemokine function. This binding was strongly inhibited by the chondroitinase digestion of versican or by the addition of soluble chondroitin sulfate (CS) B, CS E, or heparan sulfate. Furthermore, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID