IRAK2
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- JNK cascade [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- interleukin-1-mediated signaling pathway [IMP]
- intracellular signal transduction [IBA]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP, TAS]
- regulation of cytokine-mediated signaling pathway [IMP]
- response to interleukin-1 [IMP]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TIRAP
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- TIRAP-dependent toll-like receptor 4 signaling pathway [IDA]
- cell surface receptor signaling pathway [ISS]
- cellular response to bacterial lipopeptide [ISS]
- cellular response to lipoteichoic acid [ISS]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- myeloid cell differentiation [ISS]
- negative regulation of growth of symbiont in host [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of chemokine (C-X-C motif) ligand 1 production [ISS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-15 production [IDA]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [ISS]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of innate immune response [IC]
- regulation of interferon-beta production [ISS]
- response to lipopolysaccharide [IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns, with TLR-4 mediating the response to lipopolysaccharide from Gram-negative bacteria. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TIRAP IRAK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7231 | BioGRID | 3223807 | |
| TIRAP IRAK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 594071 | |
| TIRAP IRAK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TIRAP IRAK2 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID