BAIT
IL1RAP
C3orf13, IL-1RAcP, IL1R3
interleukin 1 receptor accessory protein
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TIRAP
BACTS1, Mal, MyD88-2, wyatt
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
GO Process (35)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [IDA]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- TIRAP-dependent toll-like receptor 4 signaling pathway [IDA]
- cell surface receptor signaling pathway [ISS]
- cellular response to bacterial lipopeptide [ISS]
- cellular response to lipoteichoic acid [ISS]
- defense response to Gram-positive bacterium [ISS]
- innate immune response [TAS]
- myeloid cell differentiation [ISS]
- negative regulation of growth of symbiont in host [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of chemokine (C-X-C motif) ligand 1 production [ISS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-15 production [IDA]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of protein homodimerization activity [IDA]
- positive regulation of toll-like receptor 2 signaling pathway [IMP]
- positive regulation of toll-like receptor 3 signaling pathway [ISS]
- positive regulation of toll-like receptor 4 signaling pathway [IMP]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of innate immune response [IC]
- regulation of interferon-beta production [ISS]
- response to lipopolysaccharide [IDA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns, with TLR-4 mediating the response to lipopolysaccharide from Gram-negative bacteria. All TLRs have a Toll/IL-1 receptor (TIR) domain, which is responsible for signal transduction. MyD88 is one such protein that contains a TIR domain. ... [more]
Nature Sep. 06, 2001; 413(6851);78-83 [Pubmed: 11544529]
Throughput
- Low Throughput
Curated By
- BioGRID