NCK2
Gene Ontology Biological Process
- T cell activation [NAS]
- axon guidance [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of cell proliferation [TAS]
- positive regulation of T cell proliferation [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermal growth factor-activated receptor activity [TAS]
- signal complex assembly [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
PDGFRB
Gene Ontology Biological Process
- adrenal gland development [IGI]
- aorta morphogenesis [IGI]
- cardiac myofibril assembly [IGI]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell chemotaxis [ISO]
- cell migration [ISO]
- cell migration involved in coronary angiogenesis [IMP]
- cell migration involved in vasculogenesis [IMP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- glycosaminoglycan biosynthetic process [ISO]
- hemopoiesis [IMP]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- kidney development [IMP]
- metanephric glomerular capillary formation [IGI]
- metanephric glomerular mesangial cell proliferation involved in metanephros development [IMP]
- metanephric mesenchymal cell migration [ISO]
- negative regulation of apoptotic process [ISO]
- nitrogen compound metabolic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- phosphatidylinositol metabolic process [ISO]
- phosphatidylinositol-mediated signaling [ISO]
- phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [IMP, ISO]
- platelet-derived growth factor receptor-beta signaling pathway [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of calcium ion import [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of chemotaxis [IDA]
- positive regulation of collagen biosynthetic process [ISO]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IMP]
- positive regulation of mitosis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phospholipase C activity [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of smooth muscle cell migration [IGI, IMP, ISO]
- positive regulation of smooth muscle cell proliferation [IMP, ISO]
- protein autophosphorylation [IDA, ISO]
- regulation of actin cytoskeleton organization [IGI]
- regulation of peptidyl-tyrosine phosphorylation [IMP]
- retina vasculature development in camera-type eye [IGI, IMP]
- signal transduction [IDA, ISO]
- skeletal system morphogenesis [IMP]
- smooth muscle cell chemotaxis [IGI]
- smooth muscle tissue development [IMP]
- tissue homeostasis [IMP]
Gene Ontology Molecular Function- kinase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor beta-receptor activity [ISO]
- platelet-derived growth factor binding [ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- platelet-derived growth factor-activated receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI, ISO]
- signal transducer activity [IDA]
- vascular endothelial growth factor binding [ISO]
- kinase activity [IMP]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor beta-receptor activity [ISO]
- platelet-derived growth factor binding [ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- platelet-derived growth factor-activated receptor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [ISO]
- receptor binding [IPI, ISO]
- signal transducer activity [IDA]
- vascular endothelial growth factor binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
Many of the protein-protein interactions that are essential for eukaryotic intracellular signal transduction are mediated by protein binding modules including SH2, SH3, and LIM domains. Nck is a SH3- and SH2-containing adaptor protein implicated in coordinating various signaling pathways, including those of growth factor receptors and cell adhesion receptors. We report here the identification, cloning, and characterization of a widely ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID