BAIT
PDGFRA
CD140A, PDGFR-2, PDGFR2, RHEPDGFRA
platelet-derived growth factor receptor, alpha polypeptide
GO Process (35)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac myofibril assembly [ISS]
- cell activation [TAS]
- cell chemotaxis [IMP]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic digestive tract morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- luteinization [ISS]
- metanephric glomerular capillary formation [ISS]
- negative regulation of platelet activation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [IMP, TAS]
- platelet aggregation [IMP]
- platelet-derived growth factor receptor signaling pathway [IDA]
- platelet-derived growth factor receptor-alpha signaling pathway [IMP]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of cell migration [IDA, IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IMP]
- protein autophosphorylation [IDA]
- regulation of actin cytoskeleton reorganization [TAS]
- regulation of chemotaxis [IMP]
- regulation of mesenchymal stem cell differentiation [IMP]
- retina vasculature development in camera-type eye [ISS]
- wound healing [ISS]
Gene Ontology Molecular Function- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
- platelet-derived growth factor alpha-receptor activity [IDA, IMP]
- platelet-derived growth factor binding [IDA, IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- vascular endothelial growth factor binding [IPI]
- vascular endothelial growth factor-activated receptor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
RHEB
RHEB2
Ras homolog enriched in brain
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.799600275 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.799600275, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID