PREY

PPARGC1A

LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
GO Process (32)
GO Function (12)
GO Component (3)
Homo sapiens

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.

Hentschke M, Suesens U, Borgmeyer U

The mouse nuclear receptor ERRgamma (estrogen receptor-related receptor gamma) is highly expressed in heart, skeletal muscle, kidney, and brain, as well as in the developing nervous system. We found that the expression of the coactivators PGC-1 (PGC-1alpha) and PERC (PGC-1beta) in mammalian cells augmented potently the transcriptional activation by ERRgamma. The constitutive activation function 2 (AF-2) of the orphan receptor ... [more]

Biochem. Biophys. Res. Commun. Dec. 20, 2002; 299(5);872-9 [Pubmed: 12470660]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
PPARGC1A ESRRG
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
-
ESRRG PPARGC1A
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID