ESRRG
Gene Ontology Biological Process
- intracellular receptor signaling pathway [NAS]
- multicellular organismal development [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of transcription from RNA polymerase II promoter [NAS]
- regulation of transcription, DNA-templated [ISO, NAS]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- DNA binding [NAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- calmodulin binding [NAS]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [NAS]
- protein binding [IPI]
- DNA binding [NAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- calmodulin binding [NAS]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [NAS]
- protein binding [IPI]
PPARGC1B
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- intracellular estrogen receptor signaling pathway [IDA]
- positive regulation of receptor activity [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- small molecule metabolic process [TAS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.
The mouse nuclear receptor ERRgamma (estrogen receptor-related receptor gamma) is highly expressed in heart, skeletal muscle, kidney, and brain, as well as in the developing nervous system. We found that the expression of the coactivators PGC-1 (PGC-1alpha) and PERC (PGC-1beta) in mammalian cells augmented potently the transcriptional activation by ERRgamma. The constitutive activation function 2 (AF-2) of the orphan receptor ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ESRRG PPARGC1B | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - | |
| PPARGC1B ESRRG | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID