IGF1
Gene Ontology Biological Process
- DNA replication [TAS]
- Ras protein signal transduction [TAS]
- blood coagulation [TAS]
- bone mineralization involved in bone maturation [IDA]
- cell activation [IDA]
- cellular component movement [TAS]
- cellular protein metabolic process [TAS]
- glycolate metabolic process [TAS]
- muscle hypertrophy [IMP]
- muscle organ development [TAS]
- myoblast differentiation [IDA]
- myoblast proliferation [IDA]
- myotube cell development [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of oocyte development [IMP]
- negative regulation of release of cytochrome c from mitochondria [ISS]
- negative regulation of smooth muscle cell apoptotic process [IDA]
- phosphatidylinositol-mediated signaling [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of DNA binding [IDA]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras protein signal transduction [IDA]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glucose import [IDA]
- positive regulation of glycogen biosynthetic process [IDA]
- positive regulation of glycolytic process [IDA]
- positive regulation of insulin-like growth factor receptor signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein import into nucleus, translocation [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- proteoglycan biosynthetic process [IDA]
- regulation of gene expression [IMP]
- regulation of multicellular organism growth [IEP]
- signal transduction [TAS]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IGFBP3
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- negative regulation of cell proliferation [IGI]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of signal transduction [NAS]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of myoblast differentiation [IDA]
- protein phosphorylation [IDA]
- regulation of insulin-like growth factor receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
Up to 90% of circulating insulin-like growth factors (IGF-I and IGF-II) are carried in heterotrimeric complexes with a binding protein (IGFBP) and a liver-derived glycoprotein known as the acid-labile subunit. IGFBP-3 is considered unique among the six well characterized IGFBPs in its ability to complex with the acid-labile subunit. However, a basic carboxyl-terminal domain of IGFBP-3, known to be involved ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IGFBP3 IGF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IGFBP3 IGF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IGF1 IGFBP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IGFBP3 IGF1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| IGFBP3 IGF1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| IGF1 IGFBP3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID